marula oil side effects

Marula Oil Allergies and Side Effects. Read more! Marula oil does not seem to produce any side effects, but always use a patch test if you suspect you’re sensitive to a particular oil. Potential side effects of Marula Oil include hypotension, irritation of the skin, inflammation, and gastrointestinal problems such as … Marula oil has a high content of linoleic (an omega-6 essential fatty acid) and oleic acid. Sesame Oil Side Effects. But, anecdotal evidence suggests that this oil may help in treating hair-related issues. Once smeared topically, it helps in cell division. Check out the next section to know more. It can penetrate the skin on your lips to treat dryness from within. While applying oil to your hair may seem counterintuitive (dry shampoo doesn’t grow on trees, you know), marula oil’s lightweight texture and fast absorption leaves a satin finish on your strands, without making it look greasy or weighing down your style. She specializes in writing on Health and Wellness. If you are new to using marula oil as cooking oil, you may experience stomach upset, nausea, vomiting, or indigestion. The linoleic acid found in marula oil is specifically linked to a lower occurrence of skin conditions, and a cleansing of the pores, which can help you rid yourself of those annoying acne symptoms. Find out more about these benefits in the next section. However, there is limited research on the side effects of marula oil. Sclerocarya birrea (Marula), An African Tree of Nutritional and Medicinal Uses: A Review, Food Reviews International, Taylor & Francis Online. To increase transparency to the user, we provide reference links marked by numbers in parentheses in the copy of the article. This spicy root is also good for mitigating obesity and relief from menstrual pain. It is advised not to use the same essential oil for a long period of time. Summary Marula oil is the perfect antioxidant protection recipe – the oil enhances the skin’s condition effectively. Cut rosemary on the new growth. James is an avid health freak. Avoid using this oil in case you have any allergies. Possible Side Effects of Manuka Honey Manuka honey is made in Australia and New Zealand by bees that pollinate the native manuka bush. That is why cosmetic companies use a similar approach in the production process of … Marula oil also contains high levels of antioxidants that help repair and reverse premature aging caused by free radicals. Side Effects of Marula Oil. Check them out in the next section. It is traditionally made by drying the fruit and immersing it in a base oil for a duration, after which the oil is filtered and purified. All rice noodles and rice paper wraps are gluten-free as they are made wholly from rice. More specifically, this oil comes from the nut of the fruit of the marula tree. There are a few side effects, including skin irritation, indigestion, and hypotension, but when used topically, and in moderation, there are few negative reports of this oil. Argan oil side effects relates to vitamin E in this product. You may also choose to buy an oil that combines marula oil with other beneficial natural oils such as argan or rosehip seed oil. Some may get allergic to essential oils if they prolong the use of the same essential oil. Excess usage of marula oil may cause some adverse effects like low blood pressure, skin irritation, itching, redness, and gastrointestinal problems. ✓ Evidence Based. Pout a few drops of cold-pressed pure marula oil on your fingers and apply it on your face. The raw virgin marula oil is then put through a final proprietary filtration system, before being transported to our labs in California. Manuka oil has selective antibacterial activity against Gram-positive organisms particularly S. aureus. There is also some scientific evidence that marula oil (in combination with other ingredients) may help in the treatment of wounds and scars and in the prevention of the formation of scars (3). He co-founded the literary journal, Sheriff Nottingham, and now serves as the Content Director for Stain’d Arts, a non-profit based in Denver, Colorado. An overview of the modulatory effects of oleic acid in health and disease, Mini Reviews in Medicinal Chemistry, US National Library of Medicine, National Institutes of Health. As a result, it facilitates healthy skin and hair. Save money on it buy buying a large bag (20 lb.) The active ingredients found in marula oil are able to counter those hormonal fluctuations and keep your body functioning normally. The tree is native to Africa and is very hardy and prolific, which explains why this oil is available all over the world. It is efficient in relieving dry scalp, hair loss and dandruff. It helps in preventing and treating the damage that is caused by skin aging (3). We avoid using tertiary references. According to historical sources, the marula tree played a major role for nearly 10,000 years. This is one of the reasons the oil gained so much popularity in Africa, where the tree is native, as the harsh, dehydrating environment there required extra protection against the elements. Rich.) Side effects: Marula oil is generally considered to be safe. Average rating 4.1 out of 5.0 based on 67 user(s). The fatty acids and polyphenols in it improve the elasticity of your skin with a regular application (3). In one 2010 animal study, researchers discovered that neem oil showed superior wound healing effects, compared with Vaseline. When used on the skin, marula oil is praised for being able to minimize the appearance of wrinkles and age spots, while also boosting the skin’s elasticity and helping you look younger and healthier than ever! Marula oil can be used to treat dry, damaged, and fragile hair (. Also, it may help reduce the incidence of painful and cracked skin around the nails. It all depends on your skin type. Applying this oil regularly on your hands can keep them soft. Hochst (Marula) oil: A clinical perspective, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Specifically, the rats that received topical neem oil … All it takes is 2 cups of magnesium sulfate. This juice also helps in soothing acidity. Sesame Oil as Booster for Hair and Scalp Health. Amla oil is said to stimulate hair growth and prevent hair loss and premature graying. Thus, it may help in enhancing your skin’s firmness to make it smoother. The moisturizing properties of this oil extend to the lips, hands and other commonly dry skin areas, which will not only prevent cracking and peeling but also protect those areas from infection. Marula oil possesses moisturizing and nourishing properties that may help in treating damaged or brittle nails (6). Side Effects & Safety Emu oil is possibly safe for most people when applied to the skin in appropriate amounts for up to 6 weeks. Side Effects of Marula Oil . It may also boost the natural ability of your skin to regenerate and repair itself. Whether you are applying this oil to a dry patch of skin or a sore joint or consuming it in hopes of settling your stomach, the anti-inflammatory nature of this oil can help soothe inflamed tissues and restore normal functions, even lubricating joints for sufferers of rheumatoid arthritis. Marula oil consists of vitamins C and E, oleic acid, omega-9 fatty acid, antioxidants, flavonoids, anti-bacterial and anti-aging properties. Consult a medical practitioner for health problems. The marula nut was also referred to as the food of kings, and it is from this nut that the revered “miracle oil” (i.e., marula oil) continues to be cold-pressed. It is a widely used ingredient in several cosmetic products. Marula oil has a nice balance of minerals and fatty acids that help improve elasticity. After reading about these promising benefits of marula oil, you must be wondering how to use it. Marula oil is a light yellow oil that is known for its fast-absorbing and lightweight properties. Now a new…, COVID-19 shows a wide range of manifestations among those affected. Avoid contact with eyes and stop using it in case of irritation. Like all seeds and nuts, Sesame Oil can induce an allergic reaction. Do you want the best of science-backed health & nutrition information in your inbox? However, limited research is available to prove this claim. Attach YouTube/Vimeo clip putting the URL in brackets: [https://youtu.be/Zkdf3kaso]. Marula oil is a lightweight oil that is super rich in antioxidants and fatty acids, it is derived from the kernels of the marula tree, a tree that originates from sub-Saharan tropical Africa. Excess usage of marula oil may lead to an allergic reaction. Overactive sebum glands can leave you with constantly inflamed acne and very few solutions. People who are taking medication for certain health issues, people who are at a greater risk of heart disease and strokes, patients who are about to undergo major surgery, and people with atherosclerosis are advised to consult their healthcare professionals before using marula oil. Try applying a few drops of marula oil to your hair prior to heat styling to use it as a heat protectant. Marula oil is a relative newcomer to the beauty oil scene.Its light texture and rich moisture content properties have made it a popular treatment for skin, hair, and nails. It also works well on dry and irritated scalps. It can also be produced in tincture, tea, or capsule form. There are a couple of ways that marula oil is used to improve your hair health. This is in particular with women, because of the many changes that occur in their bodies, from the monthly menstrual cycle to menopause to pregnancy. This oil gives the body a protective boost and lower levels of oxidative stress. Marula oil is also good for skin and hair. But the precise reasons behind this are less known. Known to stimulate hair growth and improve the health of your follicles, massaging a small amount of this oil into your scalp once a day can help you prevent any additional hair loss and even reverse the pattern of balding! It is also used as an ingredient in many beauty products such as soaps and perfumes. The powerful health benefits of dates include providing an energy boost, increasing iron in the body, and aiding digestion.Â. Thus, it has a moisturizing and hydrating effect on the skin (4). It is important to remember that this is a very potent oil, meaning that only a small amount is required to achieve the desired effects. Marula oil is rich in essential nutrients with numerous potential benefits. Stylecraze has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. With a healthy supply of tocopherols, antioxidants and monounsaturated fats, marula oil provides an excellent shield for the skin, defending against environmental damages and keeping the skin moisturized. Top benefits of marula oil include improved hydration and appearance of your skin. Marula oil is a product of the marula tree, scientifically known as Sclerocarya birrea. It helps in delaying the signs of aging and protects your skin from getting damaged. That is why it was used in purifying rituals before a wedding. Traditionally, the Tsonga people have used marula oil for both moisturizing effects and as a massage oil for babies. Skin problems can be effectively treated with this gentle and nourishing oil. We only allow given quantity of the selected product. It also fortifies the skin from within with a blend of moisturizing and nourishing nutrients (4). While you sleep, it is said to aid the natural renewal process of the skin to reverse the damage. These are the “good” kinds of cholesterol and can help to balance your “bad” cholesterol levels. The antioxidants and tocopherols have antibacterial properties that will keep your skin safe. Therefore, it may help reduce the inflammation, redness, itching, and dryness associated with acne. She also enjoys traveling. It can be used as an overall body lotion. This superior process ensures our Pure Marula Oil is the best organic skin care product and the highest-quality, highest-benefit beauty oil available. There are no reported side effects of using marula oil to improve your skin’s appearance and getting beautiful, lustrous hair. For this, you will have to look out for green stems. Health benefits of hibiscus tea include its ability to control hypertension & reduce high blood pressure, lower blood sugar levels, & improve liver health. The moisturizing and emollient properties of marula oil may help in treating dry cuticles and nails. Calendula oil is made by infusing the flowers in a carrier oil (such as olive oil or coconut oil). Just in case. Here are some more things about marula oil that you may find interesting. While some show severe symptoms, many remain asymptomatic. Here’s what you need to do: Though marula oil is generally safe for consumption, it does have a few side effects that you need to keep in mind. When you use marula oil as cooking oil or in culinary practices, it is possible to benefit from the many unsaturated fats in the oil. The oil ranges from clear to light yellow and has a nutty, rich aroma, which is why it is occasionally included in recipes and dishes, particularly in Africa. Organic Facts may receive a portion of revenues if you click on the sponsored ads and links by Google, Ezoic, or the Amazon Affiliate program. by John Staughton (BASc, BFA) She has hands-on experience in writing articles and press releases on Life Sciences and Healthcare, Food and Beverages, and Chemicals and Materials. But, people who are already allergic to nuts may be allergic to marula oil. from a hardware or gardening store. It is also known as the “marriage tree” and was believed to symbolize purity and fertility. Do Purple Potatoes Grow Naturally? If yes, please share your email to subscribe. Marula oil has very few side effects as reported on health however, if your skin or body is intolerant to this oil then you might observe irritation, gastrointestinal problems or hypotension, nausea and vomiting within few dosages. You can also use it at night to your nail beds. Men can use it to soften their rough skin as it is very moisturizing (4). Rub a few drops of marula oil into the ends of your hair to help eliminate split ends and dryness. This gentle oil can be applied to cure various skin and hair issues. Thus, it may play a role in keeping the scalp healthy and boosting healthy hair growth. There are two types of almond oils – Sweet and Bitter. Besides the oil, many other parts of the marula tree are used in folk medicine and for cooking in Africa (2). However, there is limited research available on the effect of marula oil on acne. There is no known danger of using emu oil over a long period of time. Ginger also helps boost bone health, strengthen the immune system, and increase appetite. This means it could help in preventing and healing a variety of skin disorders such as psoriasis, eczema, and acne. Health Benefits of Marula Fruit. Marula oil consists of good amount of linoleic acid that is an omega-6 essential fatty acid as well as omega oleic acid. Applying it twice a day may help in keeping away the hyperpigmentation and stretch marks that many women often develop. Marula oil is extracted from the kernels of marula fruits or rather from the marula nuts. A study carried out by the…. Massage Sesame Oil onto the hair and scalp to keep it shiny and strong. The abundance of oleic acid in marula oil is said to make it suitable for all skin types. James Worthington . StyleCraze provides content of general nature that is designed for informational purposes only. However, there is no scientific evidence to prove the same. Traditional and Medicinal Uses of Essential Oil Producing Tree Sclerocarya birrea in South-Central Zimbabwe, Journal of Essential Oil-Bearing Plants, ReserachGate. All rights reserved. Also called Sclerocarya Birrea Seed oil, marula oil is known for its strong moisturizing and hydrating properties . https://www.researchgate.net/publication/273333246_Traditional_and_Medicinal_Uses_of_Essential_Oil_Producing_Tree_Sclerocarya_birrea_in_South-Central_Zimbabwe, https://www.tandfonline.com/doi/abs/10.1080/87559129.2012.660716, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804067/, https://www.ncbi.nlm.nih.gov/pubmed/26528587, https://www.ncbi.nlm.nih.gov/pubmed/23278117, https://www.sciencedirect.com/science/article/pii/S0254629911001074, 11 Pure Carrier Oils You Should Consider For Your Weekend Spa Session, 20 Best Benefits Of Lavender For Skin, Hair And Health, How To Apply Oil On Hair: A Step-By-Step Guide, Hair Breakage At The Crown: Causes And How To Fix, How To Wash Hair Without Shampoo: 6 Simple Ways To Try, 32 Best Benefits Of Cucumber (Kheera) For Skin, Hair, And Health, 11 Surprising Benefits Of Turmeric Tea + How To Make It. It has several properties that can really benefit your skin’s health, including antioxidants (over 60 percent more than its argan oil cousin), anti-aging effects, and sunscreen. मारुला तेल के नुकसान – Side Effects of Marula Oil in Hindi. Marula oil is also well-known for its ability to heal dry and chapped skin (4). Quantity Request Form Dear Customer! Marula oil is rich in vitamin C and helps treat dry skin, whereas argan oil is rich in vitamin A and helps regulate sebum production. The non-greasy property of marula oil may help in treating different types of acne and act as a good moisturizer for oily skin. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. When combined with blood pressure-lowering medications, it may lower your blood pressure too much. Here is the step-by-step method to use lemongrass. Therefore, it may help fight the signs of aging like fine lines, wrinkles, dryness, and dullness. It also possesses antimicrobial properties (2). Side effects of emu oil. It may help in preventing the signs of premature aging, reducing scars and patches, treating brittle nails, and improving hair health. Kid social media influencers are promoting junk food and sugar-filled beverages in their YouTube videos, and they are garnering more than a billion views,…, We know that music, particularly musical training can improve the functioning of the brain. The oil can be used on its own or as an ingredient in ointments, balms, creams, or lotions. Marula oil contains monosaturated fatty acids, tocopherols, and amino acids (2). Apart from dry, oily, and normal skin types, it is also claimed to be suitable for sensitive skin. It can be used before applying makeup because it gets absorbed quickly. Marula Oil: the natural moisture retainer Marula oil comes from the same family as the mango and is extracted from the seed kernels. As you can read above, Epsom salt detox bath side effects are a possibility. ... Marula Side Effects. People with highly sensitive skin may experience inflammation, redness, and itching. Is Cod Liver Oil An Effective Cure For Acne? Benefits of calamansi juice include bleaching the skin, detoxifying the body, aiding in weight loss & managing diabetes. There are may hair conditioners that contain marula oil. Oleic acid is a great component for skin repair (5). The best marula oil is pure or virgin marula oil, which means it is unrefined and doesn’t contain any other ingredients. Curcumin can also limit weight gain. It is not only highly effective in treating dry skin, but also in preventing and healing a variety of skin disorders like psoriasis, eczema, acne, etc. By using this beneficial oil, you can have soft, pink lips that never crack or bleed. Try applying it after bathing for better results. You can learn more about how we ensure our content is accurate and current by reading our. Raw almonds are the source of Almond oil and the some of the benefits of almond oil come from the monounsaturated fatty acid, potassium, Vitamin E, zinc, proteins and almond oil also contains some other minerals and vitamins. There are no specific and scientifically proven risks associated with marula oil yet. Marula oil can be applied in the form of shampoo or hair conditioner to your hair. Marula oil, with its oxidative stability property, is an ideal ingredient for many cosmetic formulas such as skin lotions, scalp conditioners, and eyeshadows. Marula oil may help nourish your hair from root to tip without making it overly greasy, making it beneficial for dry, frizzy, or brittle hair. Dates are sweet fruits of the date palm tree. Use marula oil in recommended quantities to reap its benefits and consult a doctor in case of any side effects. Decoratively, calendula petals … Marula oil prevents your skin from losing its elasticity by inhibiting the activity of these (3). The many health benefits of this oil come from its rich supply of monounsaturated and polyunsaturated fats, as well as tocopherols, vitamin C, flavonoids, sterols, and other antioxidants. Enzymes like elastase and collagenase accelerate the signs of aging. Eleuthero: Is This Medicinal Herb Really Safe? () Once this oil is extracted, it can be used in a wide variety of cosmetic and cooking applications, although it is most famous for its effects on the skin and hair. John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). Advocates say … Thus, it may be effective against the bacteria that contribute to the formation of pimples and blackheads. Limited studies in wound healing and for anti-inflammatory effect have been conducted. Amla oil is a natural oil used for hair health that contains extracts from the Indian gooseberry (Phyllanthus emblica). Skin collagen levels begin to decrease during your 30’s leading to loss of elasticity. Instead of using lip balms and other lip products that do not really help, use marula oil to heal chapped lips. Antioxidants come in many different forms within marula oil, and when this oil is ingested, those antioxidants can do some serious damage to free radicals in the body. Allergic reaction to pure essential oils are rare however, some may be allergic to synthetic copies of essential oils. Therefore, it has the potential to give you flawlessly smooth skin. The antimicrobial activity of the marula oil may fight bacteria to treat scalp issues. You can use baking soda, chalk, or dishwashing liquid to loosen the stain before a wash. How to cut and dry rosemary? People who use marula oil are often those who are suffering from chronic inflammation, acne, wrinkles, premature aging, high stress, blemishes, sunburn, dandruff, hair loss, hormonal imbalances, a weak immune system, dry skin, heart problems and those who wish to lose weight, among others. Images are provided by Shutterstock & our contributors. Applying marula oil to wounds, scrapes, scratches, and cuts can help your immune system fend off pathogens and foreign substances from entering your body. Copyright © 2011 - 2020 Incnut Digital. However, there is limited research on the side effects of marula oil. How to get oil out of clothes? Marula oil may protect your skin against the damaging effects of environmental elements like the harsh rays of the sun, cold wind, and pollution. The oil constitutes a host of essential nutrients that provide excellent skin protection and skin care. Originating in Africa, marula oil is loaded with antioxidants and fatty acids that promise to keep skin — and hair — moisturized, smooth, and protected from the effects of environmental stressors and free radicals. Marula oil is extracted from the white kernels of the marula fruit's seed. SHARES. Marula oil can be used as a daytime and nighttime moisturizer, irrespective of your skin type. The following two tabs change content below. If you find those annoying white flakes on your shoulder, it may be time to turn to marula oil, which can moisturize the scalp and eliminate that dead skin before it can ever turn into dandruff. There is no scientific evidence that proves marula oil can treat your hair problems. Share Tweet Whatsapp Pinterest Linkedin Stumbleupon. Kid Influencers Promoting Junk Food On YouTube, Study Finds, Study Shows How Musical Training Improves Cognitive Function, Study Reveals Why Some People Show Severe COVID Symptoms, https://www.ajol.info/index.php/jfta/article/view/19268, http://pubs.acs.org/doi/abs/10.1021/bk-2013-1127.ch002, http://www.tandfonline.com/doi/abs/10.1080/87559129.2012.660716, https://journals.co.za/content/im_sapcr/41/9/EJC157926, http://www.sciencedirect.com/science/article/pii/S0021967301941949, http://www.sciencedirect.com/science/article/pii/S0962456205000615, http://www.sciencedirect.com/science/article/pii/S0254629911001074, http://www.sciencedirect.com/science/article/pii/S0378874101002604, http://www.sciencedirect.com/science/article/pii/S0378874114001342, http://onlinelibrary.wiley.com/doi/10.1002/ptr.3080/full, 12 Proven Health Benefits of Apple Cider Vinegar, Calamansi Juice: Benefits, Recipe, and Side Effects, Hibiscus Tea: Benefits, How to Make, & Side Effects. Rub marula oil into your cuticles after removing nail polish and let it dry. Marula is high in antioxidants. Anti-aging potential of extracts from Sclerocarya birrea (A. It is only used in some African countries for cooking. If there is no sign of hives, redness, or irritation, you can use marula oil on other parts of your body. Health benefits of apple cider vinegar include its ability to regulate blood sugar levels, boost weight loss, improve skin & gut health, & lower cholesterol levels.Read more! It is not known if emu oil is safe when taken by mouth. The entire list of reference links is also provided at the bottom of the article. Photo Credit: Shutterstock. © 2020 Organic Information Services Pvt Ltd. All the information on this website is for education purpose only. Nature’s Absolutes Cold Pressed Marula Oil for Hair and Skin, 30ml. However, there is no direct evidence to prove the same. Marula oil is used as a beautifying oil, as it helps to beautify the skin and hairs by providing them protection from the harsh environment outside. Still, as with any type of cosmetic ingredient, natural or not, there's always a risk of an actual allergy, cautions Rabach. 8.5k. Marula oil may act as an effective moisturizer for dry or aging skin because it gets absorbed quickly. Don’t rub it on your face harshly. Therefore, it is said to offer many benefits for skin, hair, and health. Marula oil has the natural ability to battle the different signs of aging. It is important to remember that this is a very potent oil, meaning that only a small amount is required to achieve the desired effects. There are very few side effects associated with marula oil, but it is possible that you will experience irritation, gastrointestinal problems or hypotension, among other minor side effects. There are quite a few impressive benefits of marula oil such as revitalizing and moisturizing the skin, preventing premature aging, reducing blemishes and age spots, fending off dandruff, stopping hair loss, boosting heart health, protecting against chronic disease, aiding weight loss efforts and soothing inflammation. Apply 3 or 4 drops of marula oil on your inner forearm. Sindhu Koganti is a Biotechnology graduate and has been in the writing field for over 4 years now. Before you start using marula oil on your skin and hair, check out the safety precautions you need to keep in mind. Offering the Marula Oil Shampoo - 730ml with fast shipping in Karachi, Lahore, Islamabad, Rawalpindi, Peshawar, Quetta and many other cities of Pakistan. Are They Good For You? Native Africans use this oil as skin moisturizer. It also has cellular regeneration, hydrating, occlusive, antimicrobial, and anti-inflammatory properties (2), (4). Marula essential oil can be applied directly or along with a shampoo, conditioner, moisturizer, lotion, etc. The excess can be blotted out gently using a tissue. When she’s not writing, she loves watching movies and listening to music. Always use scissors or pruning shears to make clean cuts. It is having a surge in popularity as a ‘miracle oil’, but we have to remember that there are rarely any plant species being discovered, only new trends, forms or … Marula oil is said to possess antioxidant, anti-aging, moisturizing, and emollient properties. In this article, we talk about the potential benefits of marula oil for hair, skin, and nails, its usage, the safety precautions to take, and its possible side effects. Marula oil is better known for its usage as an ingredient in beauty products than as cooking oil. Click here for additional information . Generally speaking, there's a very low risk of any type of side effects with marula. It is super absorbent and does not clog up the skin’s pores. Marula oil is extracted from the kernels (nuts) of the fruits of the Marula trees (Sclerocarya birrea), from the family Anacardiaceae.There are two types of marula oil, the oil extracted from the seeds and the oil extracted from the nut's hard shell. As mentioned earlier, marula oil has beneficial nutrients that help retain the skin’s elasticity and suppleness (3). This powerful oil also combats negative effects of bodily hormonal changes. Side effects of Marula oil. It has been used as a natural remedy for centuries to treat a wide range of health conditions. We source information from studies, clinical trial findings, and meta-analyses published in peer-reviewed journals. The possible side-effects of this oil can be hypotension, skin inflammation, nausea, stomach ache, and indigestion. Hochst and its chemical profiling by UPLC-Q-TOF-MS, BMC Complementary and Alternative Medicine, US National Library of Medicine, National Institutes of Health.

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